June 24, 2019


If you thought that losing weight wasn’t all just about getting into the gym, working out and also eating right then you were correct. There have been a lot of recent studies to show that our brain is closely related to how much weight we lose and why. We’ve spoken on mindset before, but this isn’t even about that. It is about the acyl-CoA-binding protein, or ACBP that has a direct influence on the neurons that allow us humans to maintain a healthy weight. Crazy right? Let’s have a little more of a look into it.

We are taking this information from CRCHUM (University of Montreal Hospital Research Centre) so any of the following materials has been official published by them and I am just using it for educational purposes. In April 2015, Thierry Alquier who is a research at CRCHUM and lead author of the study in general, had already found out that alongside his incredible team this same protein allowed astrocytes, cells that support neuronal function, to communicate with fatty acids and lipids in the blood to neurons. Now with this incredible information and further research people are now aware that the brain can actually control a human’s weight. So when we speak about mindset, and how you think or feel this could be directly related to this piece of research (if you took out the science essence of this) but basically the brain is about to adjust food intake and energy expenditure!

"With colleagues from the Université de Bordeaux's NutriNeuro laboratory, we now show that neurons that reduce food intake, known as proopiomelanocortin neurons or POMC neurons, are in 'close communication' with astrocytes that produce the protein ACBP in a specific area of the brain: the arcuate nucleus of the hypothalamus,"said Thierry Alquier, associate professor at Université de Montréal.

So in maybe an easier way to digest this information, there are two different populations of neurons in the brain that are fighting against each other and have opposing functions when activated, the first one will increase food intake and the second (also known as POMC neurons) promotes the reduction of food intake and increase in energy expenditure.


Thanks to Charlie i have managed to finally get myself back in the BEST shape of my life! Never did i think i would become addicted to exercise! or comfortable with posting photos of myself online!

 Never did i think i was going to be anything other than that chunky bloke, Charlie made a programme that was easy for me to follow and helped every step of the way, if your serious about changing not just your body but your life get in touch with him! Steve from Liverpool, UK

Is this a species issue?

"Genetic mutations explain five to 10 per cent of obesity cases,"said Alquier. "Among these cases, a large proportion is related to a disruption of this neuronal pathway commonly known as the melanocortin pathway. We observed that the deletion of the ACBP gene in astrocytes of the arcuate nucleus promotes obesity. In mice that were genetically modified to be obese, we observed in the laboratory that injecting them daily with ACBP led to a reduction of food intake and weight loss in the order of 5 per cent over five days, a mechanism that relies on the activation of POMC neurons."

However, the researcher urged caution in translating this discovery to humans. This study is at the basic research stage and was carried out in the laboratory on mice.

Recognized by the World Health Organization as a global public health problem, obesity is a major risk factor for certain chronic illnesses, such as type 2 diabetes, cardiovascular diseases and certain cancers, and for musculoskeletal disorders and premature death.


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